The relationship between frailty and major adverse cardiovascular and cerebrovascular events in Chinese older adults: the mediating effect of lipid accumulation products.

ABSTRACT:

Background

Previous studies have proven the relationship between frailty and major adverse cardiovascular and cerebrovascular events (MACCE). However, the potential mechanisms need to be further explored. This study aimed to investigate the mediating effect of lipid accumulation products (LAP) in the relationship between frailty and MACCE.

Methods

This study recruited 7901 participants aged 45 and above from wave 2011 and 2018 of the China Longitudinal Study of Health and Retirement (CHARLS). Logistic regression models were employed to examine the relationship between frailty and MACCE and the mediating effects of LAP, using the bootstrap method to confirm path effects.

Results

Frailty group presented the highest risk of MACCE (OR 1.07, 95% CI 1.03-1.10). Frailty dire

SUBMITTER: Kang Z 

PROVIDER: S-EPMC11817877 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature