Alpha-1 antitrypsin reduces inflammation and vasculopathy in mice with oxygen-induced retinopathy.

ABSTRACT:

Background

Damage to the retinal vasculature is a major cause of vision loss and is influenced by a pro-inflammatory environment within retinal tissue. Alpha-1 antitrypsin (AAT) is a potent inhibitor of serine proteases and has anti-inflammatory properties. We hypothesised that AAT could reduce inflammation and vasculopathy in neovascular retinopathies including oxygen-induced retinopathy (OIR).

Methods

Litters of C57BL/6J mice were randomised to develop OIR by exposure to high oxygen between postnatal days 7 to 12 resulting in vaso-obliteration (phase I OIR), and then room air from postnatal days 12 to 18 resulting in neovascularisation (phase II OIR). Control mice were exposed to room air. Separate cohorts of mice were administered control vehicle or human AAT (120 mg/kg)

SUBMITTER: Suphapimol V 

PROVIDER: S-EPMC11817893 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature