MAGE-A4 induces non-small cell lung cancer and tumor-promoting plasma cell accumulation.

ABSTRACT: Adaptive immunity is critical in eliminating tumors, but cancer-intrinsic factors can subvert this function. Melanoma antigen-A4 (MAGE-A4), a cancer-testis antigen, is expressed in solid tumors and correlates with poor survival, but its role in tumorigenesis and antitumor immunity remains unclear. We found that expression of MAGE-A4 was highly associated with the loss of PTEN, a tumor suppressor, in human non-small cell lung cancers (NSCLC). Here, we show that constitutive expression of human MAGE-A4 with Pten loss in mouse airway epithelia results in metastatic adenocarcinoma. Tumors showed distinct enrichment in IgA⁺ CD138⁺ CXCR4⁺ plasma cells (PCs) and increased expression of CXCL12 in endothelial cells. Consistently, human NSCLC exp

SUBMITTER: Armstrong D 

PROVIDER: S-EPMC11817953 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature