The ZNF717-rs2918520 genotype contributes to COVID-19 severity: a Taiwanese cohort study.

ABSTRACT:

Background

Coronavirus disease 2019 (COVID-19) has been a challenging pandemic since late 2019 and patients with COVID-19-related severe respiratory failure associated with high mortality rates worldwide. Genetic information such as single nucleotide polymorphisms (SNPs) serves as a predictor or prognostic factor in disease development and cancer progression. This study aimed to explore the clinical associations of SNPs with mild and severe COVID-19 symptoms in the Taiwanese population.

Methods

SARS-CoV-2-infected patients in pilot cohort study (cohort 1, n = 39) and validation cohort (cohort 2, n = 71) were enrolled. The clinical significance of SNPs in those patients with mild and severe symptoms was investigated by whole exon sequencing, polymerase chain reaction and Sang

SUBMITTER: Lin YH 

PROVIDER: S-EPMC11817965 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature