Global trends of ceftazidime-avibactam resistance in gram-negative bacteria: systematic review and meta-analysis.

ABSTRACT:

Background

The emergence of antimicrobial resistance in Gram-negative bacteria (GNB) is a major global concern. Ceftazidime-avibactam (CAZ-AVI) has been identified as a potential treatment option for complicated infections.

Objectives

This meta-analysis aimed to evaluate the global resistance proportions of GNB to CAZ-AVI comprehensively.

Methods

Studies were searched in Scopus, PubMed, and EMBASE (until September 2024), and statistical analyses were conducted using STATA software (version 20.0).

Results

CAZ-AVI resistance proportions were determined in 136 studies, with 25.8% (95% CI 22.2-29.7) for non-fermentative gram-negative bacilli and 6.1% (95% CI 4.9-7.4) for Enterobacterales. The CAZ-AVI resistance proportion significantly increased from 5.6% (95% CI 4

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11818042 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature