Sequence signature analysis of chromosome identity in three Drosophila species.

ABSTRACT:

Background

All eukaryotic organisms need to distinguish each of their chromosomes. A few protein complexes have been described that recognise entire, specific chromosomes, for instance dosage compensation complexes and the recently discovered autosome-specific Painting of Fourth (POF) protein in Drosophila. However, no sequences have been found that are chromosome-specific and distributed over the entire length of the respective chromosome. Here, we present a new, unbiased, exhaustive computational method that was used to probe three Drosophila genomes for chromosome-specific sequences.

Results

By combining genome annotations and cytological data with multivariate statistics related to three Drosophila genomes we found sequence signatures that distinguish Muller's F-elements

SUBMITTER: Stenberg P 

PROVIDER: S-EPMC1181806 | biostudies-literature | 2005 Jun

REPOSITORIES: biostudies-literature