Evidence for abundant transcription of non-coding regions in the Saccharomyces cerevisiae genome.

ABSTRACT:

Background

Recent studies in a growing number of organisms have yielded accumulating evidence that a significant portion of the non-coding region in the genome is transcribed. We address this issue in the yeast Saccharomyces cerevisiae.

Results

Taking into account the absence of a significantly large yeast EST database, we use microarray expression data collected for genomic regions erroneously believed to be coding to study the expression pattern of non-coding regions in the Saccharomyces cerevisiae genome. We find that at least 164 out of 589 (28%) such regions are expressed under specific biological conditions. In particular, looking at the probes that are located opposing other known genes at the same genomic locus, we find that 88 out of 341 (26%) of these genes support

SUBMITTER: Havilio M 

PROVIDER: S-EPMC1181813 | biostudies-literature | 2005 Jun

REPOSITORIES: biostudies-literature