Binge Eating and Obesity Differentially Alter the Mesolimbic Endocannabinoid System in Rats.

ABSTRACT: Binge eating disorder (BED) is characterized by the rapid overconsumption of palatable food in a short amount of time, often leading to obesity. The endocannabinoid system (ECS), a system involved in palatable food intake, is highly expressed in reward-related brain regions and is involved in both obesity and BED. This study investigated differences in ECS expression between these conditions using male Wistar rats exposed to specific regimen over six weeks: a non-access group (NA) with a standard diet, a continuous access group (CA) with free-choice high-fat high-sugar (fcHFHS) diet modeling obesity, and an intermittent access group (IA) with intermittent fcHFHS access modeling BED. Food intake was measured, and brain tissues from the nucleus accumbens (NAc), dorsal striatum (DS), ventral

SUBMITTER: Schoukroun F 

PROVIDER: S-EPMC11818181 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature