P2Y₁ and P2Y₁₂ Receptors Mediate Aggregation of Dog and Cat Platelets: A Comparison to Human Platelets.

ABSTRACT: Thrombosis is one of the most prevalent and serious health issues amongst humans. A key component of thrombotic events is the activation and aggregation of platelets, of which the P2Y₁ and P2Y₁₂ receptors play a crucial role in this process. Despite a breadth of knowledge on thrombosis and its mechanisms and treatment in various disorders in humans, there is less of an understanding of the expression and exact role of these receptors in companion animals such as dogs and cats. Therefore, this study aimed to investigate P2Y₁ and P2Y₁₂ receptors on dog and cat platelets in platelet-rich plasma and compare them to human platelets. Immunoblotting revealed the presence of P2Y₁ and P2Y₁₂ receptor proteins on dog and cat platelets,

SUBMITTER: Sophocleous RA 

PROVIDER: S-EPMC11818226 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature