Molecular landscape of tumor-associated tissue-resident memory T cells in tumor microenvironment of hepatocellular carcinoma.

ABSTRACT:

Background

Immunotherapy for liver cancer is used to rejuvenate tumor-infiltrating lymphocytes by modulating the immune microenvironment. Thus, early protective functions of T cell subtypes with tissue-specific residency have been studied in the tumor microenvironment (TME). We identified tumor-associated tissue-resident memory T (TA-T_RM) cells in hepatocellular carcinoma (HCC) and characterized their molecular signatures.

Methods

We obtained single-cell RNA and single-cell TCR sequencing data from five patients with HCC. The heterogeneous characteristics of T_RM cell subsets within the TME were then investigated and validated. Risk scores were calculated for survival analysis using significant core marker genes based on data from The Cancer Genome Atlas

SUBMITTER: Park MS 

PROVIDER: S-EPMC11818299 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature