Experimental and Computational Investigation of the Target and Mechanisms of <i>Gelsemium</i> Alkaloids in the Central Nervous System.

ABSTRACT: Gelsemium has a long history of medicinal use but is also a poisonous plant. Some low-toxicity alkaloids in Gelsemium exhibit anxiolytic, anti-inflammatory, analgesic, and other pharmacological effects; however, certain alkaloids in Gelsemium are highly toxic. Nevertheless, the molecular targets underlying the biological effects of Gelsemium alkaloids remain poorly understood. We employed electrophysiological techniques and molecular modeling to examine the modulatory effects of Gelsemium alkaloids on inhibitory neurotransmitter receptors, as well as to elucidate the mechanisms underlying their molecular interactions. Our findings indicate that low-toxicity alkaloids primarily exert their pharmacological effects through actions on glycine receptors, with

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11818404 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature