<i>p21</i> Promoter Methylation Is Vital for the Anticancer Activity of Withaferin A.

ABSTRACT: Breast cancer (BC) is a widespread malignancy that affects the lives of millions of women each year, and its resulting financial and healthcare hardships cannot be overstated. These issues, in combination with side effects and obstacles associated with the current standard of care, generate considerable interest in new potential targets for treatment as well as means for BC prevention. One potential preventive compound is Withaferin A (WFA), a traditional medicinal compound found in winter cherries. WFA has shown promise as an anticancer agent and is thought to act primarily through its effects on the epigenome, including, in particular, the methylome. However, the relative importance of specific genes' methylation states to WFA function remains unclear. To address this, we utilized human

SUBMITTER: Brane A 

PROVIDER: S-EPMC11818515 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature