Antibiofilm Activities of Halogenated Pyrimidines Against Enterohemorrhagic <i>Escherichia coli</i> O157:H7.

ABSTRACT: Enterohemorrhagic Escherichia coli (EHEC) is a significant public health concern due to its ability to form biofilms, enhancing its resistance to antimicrobials and contributing to its persistence in food processing environments. Traditional antibiotics often fail to target these biofilms effectively, leading to increased bacterial resistance. This study aims to explore the efficacy of novel antibiofilm agents, specifically halogenated pyrimidine derivatives, against EHEC. We screened pyrimidine and 31 halogenated pyrimidine derivatives for their antimicrobial and antibiofilm activities against EHEC using biofilm quantification assays, SEM analysis, motility, and curli production assessments. Our findings reveal that certain halogenated pyrimidine derivatives, notably 2-amino-5-brom

SUBMITTER: Jeon H 

PROVIDER: S-EPMC11818689 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature