Investigation of Biotransformation Pathways in a Chimeric Mouse with a Humanized Liver.

ABSTRACT: Xenobiotics, including drugs, undergo metabolism to facilitate detoxification and excretion. Predicting a compound's metabolic fate before clinical trials is crucial for efficacy and safety. The existing methods rely on in vitro systems and in vivo animal testing. In vitro systems do not replicate the complexity of in vivo systems, and differences in biotransformation pathways between humans and nonclinical species may occur; thus, accurate predictions of human-specific drug metabolism are not always achieved. The aim of this study was to evaluate whether a chimeric mouse with a humanized liver, specifically the PXB-mouse, can mimic human metabolic profiles. PXB-mice have livers engrafted with up to 95% human hepatocytes. The biotransformation of 12 different small-molecule drugs were eval

SUBMITTER: Karlsson IB 

PROVIDER: S-EPMC11818726 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature