Medium-Term Effect of Inhaled Nitric Oxide in Mechanically Ventilated COVID-19 Patients.

ABSTRACT: Background: Nitric oxide (NO) plays a key role in various physiological processes. Inhaled NO (iNO) has been studied for treating acute respiratory distress syndrome (ARDS). During the COVID-19 pandemic, interest grew in its potential role for patients with COVID-19 ARDS, with studies showing improved oxygenation over 48 h. Methods: This is a retrospective study of adult patients with severe COVID-19 ARDS and refractory hypoxemia admitted to the medical ICU requiring mechanical ventilation and treated with iNO. The effect on oxygenation, respiratory, and ventilation parameters is measured. Significant improvement is defined as an increase in PaO₂/FiO₂ ≥ 20% from a baseline. Results: This study includes 87 patients (55 men, mean age 58.7 ± 15.2) wi

SUBMITTER: Freidkin L 

PROVIDER: S-EPMC11818737 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature