Identification of Salivary Exosome-Derived miRNAs as Potential Biomarkers of Bone Remodeling During Orthodontic Tooth Movement.

ABSTRACT: Orthodontic tooth movement (OTM) is a complex process involving bone remodeling, and is regulated by various molecular factors, including microRNAs (miRNAs). These small, non-coding RNAs are critical in post-transcriptional gene regulation and have been implicated in the modulation of osteoclast and osteoblast activity during OTM. This study aimed to explore the expression profiles of salivary exosome-derived miRNAs during OTM to identify potential biomarkers that could provide insights into the biological processes involved in orthodontic tooth movement. Saliva samples were collected from 15 patients at three time points: before treatment (Day 0), 7 days after the treatment's onset (Day 7), and 40 days after the treatment's onset (Day 40). The exosomes were isolated, and the miRNAs were e

SUBMITTER: Kazanopoulos N 

PROVIDER: S-EPMC11818790 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature