Identifying survival-associated modules from the dysregulated triplet network in glioblastoma multiforme.

ABSTRACT:

Background

Long noncoding RNAs (lncRNAs) can act as competitive endogenous RNAs (ceRNAs) to compete with mRNAs for binding miroRNAs (miRNAs). The dysregulated triplets, composed by mRNAs, lncRNAs, and miRNAs, contributed to the development and progression of diseases, such as cancer. However, the roles played by triplet biomarkers are not fully understand in glioblastoma multiforme (GBM) patient survival.

Objectives

Here, we constructed a differential triplet interaction network (TriNet) between GBM and normal tissues and identified GBM survival related triplets.

Methods

Four significantly dysregulated modules, enriched differentially expressed molecules, were identified by integrating affinity propagation method and hypergeometric method. Furthermore, knockdown of TP

SUBMITTER: Wang JB 

PROVIDER: S-EPMC11819112 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature