Lack of TMEM27 expression is associated with postoperative progression of clinically localized conventional renal cell carcinoma.

ABSTRACT:

Purpose

In spite of early detection of conventional renal cell carcinoma (RCC) by widespread use of abdominal imaging, approximately 10-15 % of patients will die due to disease. The aim of this study was to identify new biomarkers predicting the postoperative progression of conventional RCC.

Methods

Tissue multiarrays (TMA) of conventional RCC from a cohort of 486 patients were analysed by immunohistochemistry for expression of the transmembrane protein TMEM27, which was identified as a candidate biomarker by Affymetrix U133 Plus 2.0 array. Univariate and multivariate Cox regression models were addressed to assess cancer-specific survival in association with clinicopathological variables and TMEM27 expression. Cancer-specific survival time was estimated with Kaplan-Meier ana

SUBMITTER: Javorhazy A 

PROVIDER: S-EPMC11819142 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature