Prognostic relevance of genetic variants involved in immune checkpoints in patients with colorectal cancer.

ABSTRACT:

Purpose

Genetic polymorphisms in genes involved in the immune response are already known to affect the anti-tumor immune response. This study systematically investigated the association of 14 functional SNPs in a panel of 7 genes (CCL2, CCR2, NT5E, IDO1, LAG3, PDL1, and PDCD1) involved in immune response checkpoints with the survival outcomes of Korean patients with colorectal cancer (CRC).

Methods

The genomic DNA from 668 patients with curatively resected CRC was analyzed using a Sequenom MassARRAY, along with the association with recurrence-free survival (RFS) and overall survival (OS).

Results

Among the 14 SNPs, CCL2 rs4586 and PDCD1 rs10204525 were found to have an influence on the survival outcomes of the patients with resectable CRC. CCL2 rs4586 showed a signifi

SUBMITTER: Yoon S 

PROVIDER: S-EPMC11819276 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature