Downregulated KLK13 expression in bladder cancer highlights tumor aggressiveness and unfavorable patients' prognosis.

ABSTRACT:

Purpose

Despite recent research advantages on the molecular and subcellular background, bladder cancer (BlCa) remains a clinically neglected malignancy. This is strongly reflected by the generic approach of disease diagnosis and management. Additionally, patients' prognosis became a rather demanding task due to the great disease heterogeneity. Here, we aimed to evaluate, for the first time, the clinical value of KLK13 in BlCa.

Methods

A total of 279 bladder specimens (137 tumors, 107 adjacent normal tissues and 35 healthy samples) were included. Total RNA was extracted, reverse transcribed, and KLK13 expression was assessed by quantitative real-time PCR.

Results

KLK13 expression is significantly increased in bladder tumors compared to normal adjacent epithelium. Howev

SUBMITTER: Tokas T 

PROVIDER: S-EPMC11819349 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature