Role of Mig-6 in adipose tissue: Implications for glucose metabolism and insulin resistance.

ABSTRACT:

Background

Insulin resistance is a hallmark of type 2 diabetes mellitus (T2DM) and is associated with metabolic disorders. Adipose tissue plays a crucial role in regulating whole-body energy balance and glucose homeostasis. Mitogen-inducible gene 6 (Mig-6) is a negative feedback regulator of receptor tyrosine kinases, including epidermal growth factor receptor (EGFR). This study aims to evaluate the role of Mig-6 in white adipose tissue (WAT) and its impact on systemic glucose homeostasis using Mig-6 transgenic mice.

Methods

Human visceral fat samples were obtained from four obese and three lean women undergoing hysterectomy. Adipocyte-specific Mig-6 knock-in (Mig-6AdKI) mice were generated and maintained on either a high-fat diet (HFD) or normal chow diet (NCD). Glucose tol

SUBMITTER: Kim JM 

PROVIDER: S-EPMC11819470 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature