Effects of Infant Formula Supplemented With Prebiotics on the Gut Microbiome, Gut Environment, Growth Parameters, and Safety and Tolerance: A Systematic Review and Meta-Analysis.

ABSTRACT:

Context

Prebiotics are often added to infant formulas to mimic the benefits of oligosaccharides found in human milk.

Objective

This systematic review and meta-analysis evaluated the effects of prebiotic-supplemented cow's milk-based formula on the gut microbiota, gut environment, growth parameters, and safety and tolerance in infants ≤6 months old, compared with a standard formula or human milk comparator.

Data sources

Searches were performed in the PubMed, Embase, Cochrane Central Register of Controlled Trials, and ProQuest Dissertations & Theses databases. Articles were included that reported on randomized controlled trials, were published from inception until April 2024, and met prespecified inclusion and exclusion criteria.

Data extraction

Outcomes included

SUBMITTER: Kebbe M 

PROVIDER: S-EPMC11819492 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature