A new method for the reproducible development of aptamers (Neomers).

ABSTRACT: The development of aptamers has been almost exclusively performed based on the SELEX method since their inception. While this method represents a powerful means of harnessing the in vitro evolution of sequences that bind to a given target, there are significant constraints in the design. The most significant constraint has been the reliance on counter selection on off-targets to drive specificity. Counter selection has not been as effective at driving aptamer specificity as the presence of immune tolerance, the capacity of the immune system to remove antibodies that bind to host targets, is for antibody development. This deficiency has constrained the commercial efficacy of aptamers to date. These limitations have been addressed with our design of a novel platform for aptamer identificatio

SUBMITTER: Meehan C 

PROVIDER: S-EPMC11819540 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature