Characterization of the atypical antipsychotic drug aripiprazole cytotoxicity in the neutrophil model cell line HL-60.

ABSTRACT: Atypical antipsychotics are widely used for the treatment of mental and behavioral disorders such as bipolar disorder, obsessive-compulsive disorder, and schizophrenia. However, these drugs can occasionally induce neutropenia or agranulocytosis, characterized by a significant reduction in circulating neutrophils, the primary white blood cells responsible for immune responses. This drug-induced neutropenia poses a considerable risk of life-threatening infections. However, the precise mechanism by which atypical antipsychotics induce neutropenia remains unclear. This study investigates the effects of four atypical antipsychotics, namely - aripiprazole, clozapine, olanzapine, and quetiapine - on the human neutrophil model cell line HL-60. These drugs, which modulate dopamine receptor signalin

SUBMITTER: Swain CA 

PROVIDER: S-EPMC11819542 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature