RNA-seq analysis reveals prenatal alcohol exposure is associated with placental inflammatory cells and gene expression.

ABSTRACT:

Background

Fetal alcohol spectrum disorders (FASD) are the most common preventable cause of birth defects and neurodevelopmental disorders worldwide. The placenta is the crucial interface between mother and fetus. Prenatal alcohol exposure (PAE) has been shown to alter placental structure and expression of genes in bulk placental tissue samples, but prior studies have not examined effects on placental cell-type composition or taken cell-type into consideration in transcriptome analyses.

Methods

We leveraged an existent placenta single-cell RNA-seq dataset to perform cell-type deconvolution of bulk placental RNA-seq data from 35 heavy drinking pregnant women and 33 controls in a prospective birth cohort in Cape Town, South Africa. We used bivariate analyses and multivariable

SUBMITTER: Williams RP 

PROVIDER: S-EPMC11819563 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature