Pilot randomized trial of the effect of antibacterial mouthwash on muscle contractile function in healthy young adults.

ABSTRACT: Antiseptic mouthwash use is widespread due to its oral health benefits. However, its impact on systemic physiological processes, particularly nitric oxide (NO) bioavailability and muscle contractility, is not fully understood. We sought to determine the effects of cetylpyridinium (antibacterial) versus sodium chloride (control) mouthwashes on salivary and breath NO markers and muscle contractile function in healthy young adults. Thirty participants (n = 15/group) completed a randomized, parallel-arm, blinded trial, comparing the two mouthwashes before and after 7 d of treatment. NO bioavailability was inferred via measurement of salivary nitrate (NO3-), nitrite (NO2-), and cyclic guanyl monophosphate (cGMP) concentrations and breath NO level. Contractile function of the knee extensor muscl

SUBMITTER: Gallardo EJ 

PROVIDER: S-EPMC11819566 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature