Cobalamin Deficiency in Children and Adolescents with Sickle Cell Disease.

ABSTRACT: Background/Objective: Cobalamin (B₁₂) deficiency is reported in 18% of adults with sickle cell disease (SCD) and only 10% without SCD; limited data are available on children. Diagnosing B₁₂ deficiency is challenging given the lack of an established gold standard method of assessment and the unique renal features of SCD. B₁₂ metabolism can be impacted by the clinical use of nitrous oxide gas (N₂O), which is a standard therapy for SCD pain in some European countries. In response to emerging reports of neurologic sequalae in patients with SCD receiving N₂O, we evaluated the prevalence of B₁₂ deficiency in children with SCD pain. Methods: Secondary analysis of prospective blood and urine samples in children aged 3-

SUBMITTER: Hatabah D 

PROVIDER: S-EPMC11819659 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature