Latent Association Between Diets and Glioma Risk: A Mendelian Randomization Analysis.

ABSTRACT:

Background

Gliomas, particularly high-grade gliomas such as glioblastoma, represent a major challenge due to their poor prognosis. While dietary factors have been proposed as potential modulators of glioma risk, causal inference has been hindered by confounding and reverse causality in observational studies. This study employs Mendelian randomization to investigate the causal relationship between dietary factors and glioma risk.

Methods

A two-sample MR framework was applied, utilizing genome-wide association study data for 22 dietary exposures and glioma risks, including both GBM and non-GBM subtypes. Instrumental variables (genetic variants) were identified for each dietary factor to address confounding and pleiotropy. Causal inference was conducted using inverse-variance w

SUBMITTER: Zhao J 

PROVIDER: S-EPMC11819737 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature