Isolation and Bioassay of Linear Veraguamides from a Marine Cyanobacterium (<i>Okeania</i> sp.).

ABSTRACT: Marine cyanobacteria have gained momentum in recent years as a source of novel bioactive small molecules. This paper describes the structure elucidation and pharmacological evaluation of two new (veraguamide O (1) and veraguamide P (2)) and one known (veraguamide C (3)) analogs isolated from a cyanobacterial collection made in the Las Perlas Archipelago of Panama. We hypothesized that these compounds would be cytotoxic in cancer cell lines. The compounds were screened against HEK-293, estrogen receptor positive (MCF-7), and triple-negative breast cancer (MDA-MB-231) cells as well as against a broad panel of membrane-bound receptors. The planar structures were determined based on NMR and MS data along with a comparison to previously isolated veraguamide analogs. Phyloge

SUBMITTER: Parker SJ 

PROVIDER: S-EPMC11819893 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature