In Vitro CO-Releasing and Antioxidant Properties of Sulfonamide-Based CAI-CORMs in a H₂O₂-Stimulated Human Achilles Tendon-Derived Cell Model.

ABSTRACT: Tendinopathy is often described as a complex and multifactorial condition which affects tendons. Tendon disorders are marked by a reduction in mechanical function, accompanied by pain and swelling. At the molecular level, tendinopathy leads to oxidative stress-driven inflammation, increased cell death, disruption of extracellular matrix balance, abnormal growth of capillaries and arteries, and degeneration of collagen formation. Here, we report an innovative approach to modulate oxidative stress during tendinopathy based on sulfonamide-based Carbonic Anhydrase Inhibitors-carbon monoxide releasing molecules (CAI-CORMs) hybrids endowed with dual carbon monoxide (CO) releasing activity and carbonic anhydrase (CA) inhibition. The synthesised compounds have been studied in a model of human Achi

SUBMITTER: Berrino E 

PROVIDER: S-EPMC11819963 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature