Medication-Induced Weight Change Across Common Antidepressant Treatments : A Target Trial Emulation Study.

ABSTRACT:

Background

Antidepressants are among the most commonly prescribed medications, but evidence on comparative weight change for specific first-line treatments is limited.

Objective

To compare weight change across common first-line antidepressant treatments by emulating a target trial.

Design

Observational cohort study over 24 months.

Setting

Electronic health record (EHR) data from 2010 to 2019 across 8 U.S. health systems.

Participants

183 118 patients.

Measurements

Prescription data determined initiation of treatment with sertraline, citalopram, escitalopram, fluoxetine, paroxetine, bupropion, duloxetine, or venlafaxine. The investigators estimated the population-level effects of initiating each treatment, relative to sertraline, on mean weight cha

SUBMITTER: Petimar J 

PROVIDER: S-EPMC11819980 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature