Comparative Analysis of Metabolites of Wild and Cultivated <i>Notopterygium incisum</i> from Different Origins and Evaluation of Their Anti-Inflammatory Activity.

ABSTRACT: The dried rhizome of Notopterygium incisum (NI) from the Umbelliferae family, genuinely produced in Sichuan, China, is a classic traditional Chinese medicinal herb for treating wind-dampness arthralgia. Due to scarce natural resources, wild NI is gradually being replaced by cultivated types. However, knowledge is limited regarding the differences in chemical composition and pharmacological effects between wild and cultivated NI and between Sichuan-grown and other-region-grown NI. In this study, a plant metabolomics strategy, based on GC-MS and UHPLC-Orbitrap MS, was employed to compare metabolic profiles between wild and cultivated NI and between cultivated NI from Sichuan and cultivated NI from Gansu and Qinghai. In total, 195 metabolites were identified, and the biosyntheti

SUBMITTER: Kong F 

PROVIDER: S-EPMC11820002 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature