New Benzothiazole-Monoterpenoid Hybrids as Multifunctional Molecules with Potential Applications in Cosmetics.

ABSTRACT: The Thymus vulgaris and Origanum vulgare essential oils (contained thymol and carvacrol in a range of 35-80%) are used in various products in the fields of medicine, cosmetics, and foods. Molecular hybridization between benzothiazole (BT) and phenolic monoterpenoids is a promising method for the development of biologically active compounds. New benzothiazole-monoterpenoid hybrids were synthesized through a regioselective α-amidoalkylation reaction of thymol and carvacrol with high yields (70-96%). This approach is both simple and cost-effective, employing easily accessible and inexpensive reagents to produce target molecules. The structure of the synthesized compounds was characterized spectrally using ¹H-, ¹³C-NMR, FT-IR, and HRMS data. The newly

SUBMITTER: Kirkova D 

PROVIDER: S-EPMC11820011 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature