Evaluation of Polymeric Micro/Nanofibrous Hybrid Scaffolds Prepared via Centrifugal Nozzleless Spinning for Tissue Engineering Applications.

ABSTRACT: We compared the applicability of 3D fibrous scaffolds, produced by our patented centrifugal spinning technology, in soft tissue engineering. The scaffolds were prepared from four different biocompatible and biodegradable thermoplastics, namely, polylactide (PLA), polycaprolactone (PCL), poly(3-hydroxybutyrate) (PHB), and poly(1,4-butylene succinate) (PBS) and their blends. The combined results of SEM and BET analyses revealed an internal hierarchically organized porosity of the polymeric micro/nanofibers. Both nanoporosity and capillary effect are crucial for the water retention capacity of scaffolds designed for tissue engineering. The increased surface area provided by nanoporosity enhances water retention, while the capillary effect facilitates the movement of water and nutrients within

SUBMITTER: Beran M 

PROVIDER: S-EPMC11820018 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature