Metabolite-Induced Apoptosis by <i>Gundelia tournefortii</i> in A549 Lung Cancer Cells: A Cytotoxic and Gene Expression Study.

ABSTRACT:

Background/objectives

Gundelia tournefortii (Kenger) is a traditional medicinal plant and exhibits potential anticancer properties. This study investigates the cytotoxic and apoptotic effects of its water extract on human lung carcinoma A549 cells.

Methods

A lung cancer cell line was treated with Gundelia tournefortii extract. The metabolic content of the extract that plays key roles in anticancer was detected by high-performance liquid chromatography. Anticancer properties were further detected by a flow cytometer apoptosis assay, and signaling pathways were determined by a PCR array through hub gene expression alteration. Gene enrichment analysis and network pharmacology correlated metabolites and pathways that were involved in anticancer effects.

Results<

SUBMITTER: Yuksel A 

PROVIDER: S-EPMC11820080 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature