The Effects of a Novel <i>Astragalus</i>-Based Extract (Keyfobell Powder (KFB)) on Longitudinal Bone Growth via IGF-1 Upregulation: A Potential Growth Hormone Alternative.

ABSTRACT:

Background/objectives

This study evaluated the effects of a novel Astragalus extract (Keyfobell powder [KFB]) composed of Astragalus membranaceus, red ginseng (Panax ginseng C. A. Meyer), and Cervi Parvum Cornu as a potential growth hormone (GH) alternative. The primary focus was placed on its impact on longitudinal bone growth through the upregulation of circulatory insulin-like growth factor (IGF)-1.

Methods

We performed in vitro and in vivo experiments using a hypothalamic cell line and Sprague-Dawley (SD) rats. Quantitative RT-PCR was performed to determine growth hormone-releasing hormone (GHRH) and ghrelin mRNA expressions in GT1-7 cells. The treatment groups were administered KFB at various dosages, and the positive controls received recombinant h

SUBMITTER: Lee MJ 

PROVIDER: S-EPMC11820268 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature