Molecular Properties of Phosphodiesterase 4 and Its Inhibition by Roflumilast and Cilomilast.

ABSTRACT: Phosphodiesterase 4 (PDE4) catalyzes cyclic adenosine monophosphate (cAMP) hydrolysis, playing a crucial role in the cAMP signaling pathway. cAMP is a secondary messenger involved in numerous physiological functions, such as inflammatory responses, immune responses, neural activity, learning, and memory. PDE4 inhibition is important for controlling anti-inflammatory and neuroprotective effects. In this review, we provide a comprehensive overview of the molecular functions and properties of human PDE4s. The study presents detailed sequence information for the PDE4 isoforms and the structural properties of the catalytic domain in members of the PDE4 family. We also review the inhibitory effects of the PDE4 inhibitors roflumilast and cilomilast related to respiratory diseases in PDE4. The cry

SUBMITTER: Kwak HJ 

PROVIDER: S-EPMC11820465 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature