Mechanochemistry to Form Substituted Imidazoles, Imidazolium Salts and NHC-Gold Complexes with Fluorine-Containing Groups.

ABSTRACT: Synthesis of organometallic compounds has had an enormous impact on medicine. In this context, gold complexes are gaining much interest since the discovery of the cytotoxic effect of cisplatin. On the other hand, in the last two decades, the mechanochemical synthetic approaches have been developed considerably demonstrating that they could also be a powerful tool enabling environmentally benign and sustainable synthesis of metal complexes. The present work focuses on mechanochemical synthesis of precursors and gold-NHC complexes of type NHCAuCl and [AubisNHC]⁺. The mechanochemical approach has been studied to afford four substituted imidazoles, eight imidazolium salts and six NHCAuCl and one [AubisNHC]⁺. Substituted imidazoles were obtained with yields varying between

SUBMITTER: Salis C 

PROVIDER: S-EPMC11820496 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature