Bioactive Potential and Chemical Composition of <i>Vitex agnus-castus</i> L. Leaf Extracts Collected in Algeria: A Combined In Vitro and In Silico Approach.

ABSTRACT: Vitex agnus-castus L., a medicinal plant widespread in the Middle East and Europe, is traditionally used to treat various disorders. In this study, extracts from its leaves, collected in Algeria, were evaluated for their antioxidant, enzymatic, and antibacterial activities through in vitro and in silico studies. The hydroalcoholic extract was fractionated using solvents of varying polarity to isolate bioactive compounds with potential biological effects. Notable levels of total phenolics, flavonoids, and flavonols were detected in the dichloromethane (CH₂Cl₂) and ethyl acetate (EtOAc) extracts. NMR and GC-MS were used to identify metabolites in the extracts, which were discussed in relation to their biological activities. Antioxidant assays showed that the EtOA

SUBMITTER: Bramki A 

PROVIDER: S-EPMC11820499 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature