Antimicrobial Lobophorins from Endophytic Strain <i>Streptomyces</i> sp. R6 Obtained from <i>Azadirachta indica</i>.

ABSTRACT: Endophytic bacteria are an important source for developing antimicrobial substances. With the aim to find eco-friendly antimicrobial agents from natural sources, Streptomyces sp. R6 was isolated from Azadirachta indica. After that, a new spirotetronate natural product, lobophorin S (compound 2), together with lobophorin H8 (compound 1) and a known macrolide compound divergolide C (compound 3) were isolated from the cultural solution of strain R6. These compounds mark the first isolation of marine-derived microbial natural products known as lobophorins (LOBs) from endophytic bacteria. The structures of these three compounds were identified by extensive NMR and HRMS analyses. The antimicrobial activities of these three compounds against eight fungal and fou

SUBMITTER: Chen X 

PROVIDER: S-EPMC11820565 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature