Integrating an Extended-Gate Field-Effect Transistor in Microfluidic Chips for Potentiometric Detection of Creatinine in Urine.

ABSTRACT: Monitoring creatinine levels in urine helps to recognize kidney dysfunction. In this research, we developed a photocurable membrane for the detection of serum creatinine. Using a system based on field-effect transistors, we carried out creatinine quantification in synthetic urine. The device was able to cover values between 3 and 27 mmol L^-1. The current sensitivity was 0.8529 (mA)^1/2 mmol^-1 L with 91.8% linearity, with the LOD and LOQ being 5.3 and 17.5 mmol L^-1, respectively. The voltage sensitivity was 0.71 mV mmol^-1 L with a linearity of 96.2%, with the LOD and LOQ being 4.2 and 14.0 mmol L^-1, respectively. These data were obtained under flow conditions. The system performed very well during the measurements, with a hyst

SUBMITTER: De Brito Oliveira DC 

PROVIDER: S-EPMC11820648 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature