Insights on the Mechanisms of the Protective Action of Naringenin, Naringin and Naringin Dihydrochalcone on Blood Cells in Terms of Their Potential Anti-Atherosclerotic Activity.

ABSTRACT: Atherosclerosis is caused by injury to the blood arteries and progressive oxidative stress. Blood cells play an important role in its development; thus, their protection is important. Naringenin (N) is documented to possess a protective action against atherosclerosis, and we hypothesize that its derivatives, naringin (Nr) and naringin dihydrochalcone (Nd), with slightly different structures, possess similar or better activity. Therefore, this research aimed to find the mechanism of protective action of N, Nr and Nd in relation to erythrocytes, peripheral blood mononuclear cells (PBMCs) and platelets in terms of their potential anti-atherosclerotic effect. Moreover, their physicochemical properties and the interaction of flavonoids with liposomes were studied. All flavonoids protected eryth

SUBMITTER: Kazmierczak T 

PROVIDER: S-EPMC11820682 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature