Ultraprecise Detection of Influenza Virus by Antibody-Modified Graphene Transistors.

ABSTRACT: Over the past decade, the large-scale spread of influenza viruses has posed an increasing burden on public health. The effective screening of influenza agents requires a fast, precise, on-site and easy-to-operate method. Unfortunately, current screening methods face challenges in speed and accuracy, especially in complex on-site settings. Here, this work develops a nucleoprotein antibody-modified graphene field-effect transistor (NPAb-GFET) for rapid and highly precise detection of influenza A viruses. The functionalized monoclonal antibodies capture influenza virus nucleoprotein within 100 × 10^-9 s on the sensing surface. Therefore, the developed NPAb-GFET achieves an average response time of 72.1 s when detecting influenza A viruses in clinical samples. Furthermore, the testin

SUBMITTER: Wang G 

PROVIDER: S-EPMC11820836 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature