Predicting the Key Properties of a Modified Product to Pre-Select a Pluronic F127 Modification Scheme for Preparing High-Quality Nano-Micelles.

ABSTRACT: Hydrophobic modification alters the properties of Pluronic F127 to form micelles more efficiently and enhances its drug-loading capacity. However, selecting the appropriate hydrophobic group for modification is laborious. In this paper, we propose an efficient approach for predicting key parameters to select hydrophobic groups for F127 modification prior to synthesis, in order to improve the formability and stability of the micelles. The results of nuclear magnetic resonance and isothermal titration calorimetry were utilized to establish a function for predicting the hydrophile-lipophile balance, critical micelle concentration, and Gibbs free energy of the products based on the structure of raw material. These predicted values can assist us in selecting suitable hydrophobic groups for F127

SUBMITTER: Song J 

PROVIDER: S-EPMC11821254 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature