The significance of CD49f expression in pediatric B-cell acute lymphoblastic leukemia.

ABSTRACT:

Objectives

CD49f is an adhesion molecule present on malignant lymphoblasts in B-cell acute lymphoblastic leukemia; it is associated with a poor prognosis. CD49f expression has been proposed as a marker for measurable residual disease (MRD) marker, but this marker has yet to be implemented in clinical practice.

Methods

In this study, we used flow cytometry to detect CD49f expression by leukemic blasts in paired bone marrow and cerebrospinal fluid samples at diagnosis and bone marrow at day 15 of treatment.

Results

At diagnosis, 93% of bone marrow and 100% of cerebrospinal fluid lymphoblasts expressed CD49f. The intensity of CD49f expression statistically significantly increased during treatment (P < .001). In MRD-negative end-of-treatment samples, only a small populati

SUBMITTER: Hunyadi A 

PROVIDER: S-EPMC11821268 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature