Histomorphologic spectrum of nodal marginal zone lymphoma as defined by its methylome.

ABSTRACT:

Objectives

Primary nodal marginal B-cell lymphoma (NMZL) is rare and histologically very variable. Its large-cell presentation is difficult to distinguish from nodal diffuse large B-cell lymphoma (nDLBCL) due to the absence of specific markers for nodal marginal zone lymphomas in general.

Methods

Using a comprehensive cohort of NMZLs and a control cohort of nDLBCLs, we conducted a methylome analysis on subgroups of both.

Results

The methylomes were strikingly different between the cohorts but unexpectedly homogeneous within the NMZL cohort. This allowed us to describe the morphologic spectrum of NMZL in all its value ranges. The considerable overlap in growth pattern and cytology of NMZL with nDLBCL was explored morphometrically, leading to an operational tool for sep

SUBMITTER: Spada F 

PROVIDER: S-EPMC11821272 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature