Biological subphenotypes in patients hospitalized with suspected infection in Thailand: a secondary analysis of a prospective observational study.

ABSTRACT:

Background

Subphenotypes of infected patients have been reported in Europe and North America, but few studies have investigated populations in Southeast Asia. We sought to identify and differentiate subphenotypes of patients hospitalized with suspected infection in rural Thailand using biological markers implicated in the dysregulated host response.

Methods

In a cohort of prospectively enrolled patients hospitalized with suspected infection in northeastern Thailand, we measured 15 circulating biomarkers from a random selection of 585 subjects and developed latent profile models to identify subphenotypes. Patient characteristics were compared after subphenotype assignment, and a parsimonious model was developed to identify patient subphenotypes.

Findings

We identified

SUBMITTER: Poolchanuan P 

PROVIDER: S-EPMC11821389 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature