RNase Y mediates posttranscriptional control of the virulence-associated CncR1 small-RNA in <i>Helicobacter pylori</i>.

ABSTRACT: Ribonucleases are involved in several biological processes, including the turnover of structural and messenger RNAs and the specific processing of the cellular transcriptome. Here, we characterized the RNase Y from Helicobacter pylori. We found that RNase Y is membrane-associated and its expression is controlled during bacterial growth and by Fur in response to iron. We observed that RNase Y deletion has a limited impact on H. pylori transcriptome and on bacterial growth. Interestingly, we found that RNase Y is involved in the metabolism of CncR1, a virulence-associated sRNA oppositely modulating bacterial motility and adhesion to host cells. Indeed, RNase Y inactivation led to the accumulation of a 3'-extended CncR1 isoform, which appeared unable to interact in vitro

SUBMITTER: D'Agostino F 

PROVIDER: S-EPMC11821409 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature