Evaluation of microRNAs as liquid biopsy markers in adrenocortical tumors.

ABSTRACT:

Introduction

Adrenal tumors (ATs) encompass a wide differential diagnosis, necessitating a multi-step process for accurate identification. Liquid biopsy emerges as a promising non-invasive technique for distinguishing between malignant and benign, as well as hyperfunctioning and non-functioning cases. Recent studies have highlighted the potential of microRNAs as circulating biomarkers; however, their clinical utility remains underexplored. This study aims to validate the diagnostic performance of selected circulating microRNAs, (miR-483-5p, miR-210, miR-335 and miR-22-3p), identified through microRNA profiling studies, as markers of malignancy or cortisol hypersecretion in a cohort of patients with ATs.

Methods

We collected serum samples from 75 patients with ATs, including

SUBMITTER: Mytareli C 

PROVIDER: S-EPMC11821491 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature