Specification of claustro-amygdalar and palaeocortical neurons and circuits.

ABSTRACT: The ventrolateral pallial (VLp) excitatory neurons in the claustro-amygdalar complex and piriform cortex (PIR; which forms part of the palaeocortex) form reciprocal connections with the prefrontal cortex (PFC), integrating cognitive and sensory information that results in adaptive behaviours^1-5. Early-life disruptions in these circuits are linked to neuropsychiatric disorders^4-8, highlighting the importance of understanding their development. Here we reveal that the transcription factors SOX4, SOX11 and TFAP2D have a pivotal role in the development, identity and PFC connectivity of these excitatory neurons. The absence of SOX4 and SOX11 in post-mitotic excitatory neurons results in a marked reduction in the size of the basolateral amygdala complex (BLC), claustrum (CL

SUBMITTER: Kaur N 

PROVIDER: S-EPMC11821539 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature